In-depth analysis of compartmentalization of HIV-1 matrix protein p17 in PBMC and plasma
Autor: | Selleri, M., Dolcetti, R., Caccuri, F., Giombini, E., Rozera, G., Abbate, I., Mammone, A., Zanussi, S., Martorelli, D., SIMONA FIORENTINI, Caruso, A., Capobianchi, M. R. |
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Rok vydání: | 2017 |
Předmět: | |
Zdroj: | Scopus-Elsevier Europe PubMed Central |
ISSN: | 1121-7138 |
Popis: | HIV-1 p17 plays an important role in the virus life-cycle and disease pathogenesis. Recent studies indicated a high heterogeneity of p17. A high number of insertions in the p17 carboxy-terminal region have been more frequently detected in patients with non-Hodgkin lymphoma (NHL), suggesting a role of altered p17 in lymphomagenesis. Based on p17 heterogeneity, possible PBMC/plasma compartmentalization of p17 variants was explored by ultra-deep pyrosequencing in five NHL patients. The high variability of p17 with insertions at the carboxy-terminal region was confirmed in plasma and observed for the first time in proviral genomes. Quasispecies compartmentalization was evident in 4/5 patients. Further studies are needed to define the possible role of p17 quasispecies compartmentalization in lymphomagenesis. |
Databáze: | OpenAIRE |
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