Birth weight and risk of childhood solid tumors in Brazil: a record linkage between population-based data sets
| Autor: | Silva, Neimar de Paula, Reis, Rejane de Souza, Cunha, Rafael Garcia, Oliveira, Julio Fernando, de Lima, Cristina Fernanda da Silva, Pombo-de-Oliveira, Maria Socorro, Santos, Marceli Oliveira, de Camargo, Beatriz |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
lcsh:Arctic medicine. Tropical medicine Databases Factual sistema de registros lcsh:RC955-962 fetal development neoplasms lcsh:Medicine Cohort Studies Risk Factors desarrollo fetal Humans Child peso al nacer Original Research Child health neoplasias Brasil lcsh:Public aspects of medicine lcsh:R birth weight registries Salud del niño lcsh:RA1-1270 Case-Control Studies Female Medical Record Linkage Brazil |
| Zdroj: | Revista Panamericana de Salud Pública, Vol 41, Iss 0 (2017) Revista Panamericana de Salud Pública |
| ISSN: | 1680-5348 |
| Popis: | Objective. To analyze the relationship between the development of childhood solid tumors and 1) birth weight and 2) fetal growth, using two Brazilian population-based data sets. Methods. A case–cohort study was performed using two population-based data sets, and linkage between the Live Birth Information System (Sistema de Informação sobre Nascidos Vivos, SINASC) and 14 population-based cancer registries (PBCRs) was established. Four controls per case were chosen randomly from the SINASC data set. Tumors were classified as central nervous system (CNS), non-CNS embryonal, and other tumors (“miscellaneous”). Adjustments were made for potential confounders (maternal age, mode of delivery, maternal education, birth order, gestational age, sex, and geographic region). Odds ratios (ORs) with 95% confidence intervals (CIs) were computed using unconditional logistic regression analysis. Results. In a trend analysis, for every 500 g of additional birth weight, the crude OR was 1.12 (CI: 1.00–1.24) and the adjusted OR was 1.02 (CI: 0.90–1.16) for all tumors. For every 1 000 g of additional birth weight, the crude OR was 1.25 (CI: 1.00–1.55) and the adjusted OR was 1.04 (CI: 0.82–1.34) for all tumors. Among children diagnosed after reaching the age of 3 years, in the miscellaneous tumor category, the OR was significantly increased for every additional 500 g and 1 000 g of birth weight. Conclusions. The study data suggested that increased birth weight was associated with childhood solid tumor development, especially among children more than 3 years old with “miscellaneous” tumors. |
| Databáze: | OpenAIRE |
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