MiR-155-5p and MiR-203a-3p Are Prognostic Factors in Soft Tissue Sarcoma
| Autor: | Greither, Thomas, Koser, Franziska, Holzhausen, Hans-Jürgen, Güttler, Antje, Würl, Peter, Kappler, Matthias, Wach, Sven, Taubert, Helge |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cancers Cancers, Vol 12, Iss 2254, p 2254 (2020) Volume 12 Issue 8 |
| ISSN: | 2072-6694 |
| Popis: | Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with a five-year survival rate of approximately 50%. Reliable molecular markers for risk stratification and subsequent therapy management are still needed. Therefore, we analyzed the prognostic potential of miR-155-5p and miR-203a-3p expression in a cohort of 79 STS patients. MiR-155-5p and miR-203a-3p expression was measured from tumor total RNA by qPCR and correlated with the demographic, clinicopathological, and prognostic data of the patients. Elevated miR-155-5p expression was significantly associated with increased tumor stage and hypoxia-associated mRNA/protein expression. High miR-155-5p expression and low miR-203a-3p expression, as well as a combination of high miR-155-5p and low miR-203a-3p expression, were significantly associated with poor disease-specific survival in STS patients in the Kaplan&ndash Meier survival analyses (p = 0.027, p = 0.001 and p = 0.0003, respectively) and in the univariate Cox regression analyses (RR = 1.96 p = 0.031 RR = 2.59 p = 0.002 and RR = 4.76 p = 0.001, respectively), but not in the multivariate Cox regression analyses. In conclusion, the oncomiR miR-155-5p and the tumor suppressor-miR miR-203a-3p exhibit an association with STS patient prognosis and are suggested as candidates for risk assessment. |
| Databáze: | OpenAIRE |
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