Effect of Ochratoxin A on human haematopoietic progenitors proliferation and differentiation: an in vitro study
| Autor: | R, Froquet, G, Le Dréan, D, Parent-Massin |
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| Přispěvatelé: | Laboratoire de Microbiologie et de Sécurité Alimentaire ( ISAMOR), Université de Brest (UBO) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Erythroid Precursor Cells
Hematopoiesis/drug effects Cell Differentiation Megakaryocytes/cytology Mycotoxins Megakaryocytes/metabolism Ochratoxins Hematopoiesis Mycotoxins/toxicity [SDV.TOX]Life Sciences [q-bio]/Toxicology Ochratoxins/toxicity Humans Megakaryocytes [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Cell Division Cells Cultured Megakaryocytes/drug effects |
| Zdroj: | Human and Experimental Toxicology Human and Experimental Toxicology, SAGE Publications, 2003, 22 (7), pp.393-400. ⟨10.1191/0960327103ht375oa⟩ |
| ISSN: | 0960-3271 1477-0903 |
| DOI: | 10.1191/0960327103ht375oa⟩ |
| Popis: | International audience; Ochratoxin A (OTA) is a mycotoxin food and feed-contaminant known to induce nephro and hepatotoxicity in human and animal, and related to human Balkan Endemic Nephropathy. However, haematological troubles are also observed in case of acute OTA intoxication. These disorders observed in animals emphasise the necessity to determine if OTA exposure induce damage to haematopoietic system in human. The effect on haematopoiesis has been evaluated using in vitro clonogenic assays of the three lineages i.e., platelet, red and white blood cell progenitors. Human erythroblastic and granulomonocytic progenitor proliferation is decreased in the presence of 10(2) microM OTA. Platelet progenitors were destroyed at 10(2) microM OTA. For the lowest concentrations haematopoietic progenitor proliferation is not affected by OTA. Comparison with other mycotoxins known to be myelotoxic shows that OTA is less myelotoxic than trichothecenes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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