Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention

Autor: Karim, Quarraisha, Archary, Derseree, Barré-Sinoussi, Françoise, Broliden, Kristina, Cabrera, Cecilia, Chiodi, Francesca, Fidler, Sarah, Gengiah, Tanuja, Herrera, Carolina, Kharsany, Ayesha, Liebenberg, Lenine, Mahomed, Sharana, Menu, Elisabeth, Moog, Christiane, Scarlatti, Gabriella, Seddiki, Nabila, Sivro, Aida, Cavarelli, Mariangela
Přispěvatelé: University of KwaZulu-Natal [Durban, Afrique du Sud] (UKZN), Columbia University [New York], Institut Pasteur [Paris] (IP), Karolinska Institutet [Stockholm], Universitat Autònoma de Barcelona (UAB), Imperial College London, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Mucosal Immunity and Sexually Transmitted Infection Control (MISTIC), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), IRCCS Ospedale San Raffaele [Milan, Italy], Public Health Agency of Canada [Winnipeg]
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Immunology
Frontiers in Immunology, 2022, 13, pp.1055042. ⟨10.3389/fimmu.2022.1055042⟩
ISSN: 1664-3224
DOI: 10.3389/fimmu.2022.1055042⟩
Popis: on behalf of FEMIN and CAPRISA, Centre for the AIDS Programme of Research in South Africa (CAPRISA); International audience; Preventing new HIV infections remains a global challenge. Young women continue to bear a disproportionate burden of infection. Oral pre-exposure prophylaxis (PrEP), offers a novel women-initiated prevention technology and PrEP trials completed to date underscore the importance of their inclusion early in trials evaluating new HIV PrEP technologies. Data from completed topical and systemic PrEP trials highlight the role of gender specific physiological and social factors that impact PrEP uptake, adherence and efficacy. Here we review the past and current developments of HIV-1 prevention options for women with special focus on PrEP considering the diverse factors that can impact PrEP efficacy. Furthermore, we highlight the importance of inclusion of female scientists, clinicians, and community advocates in scientific efforts to further improve HIV prevention strategies.
Databáze: OpenAIRE
Externí odkaz: