| Přispěvatelé: |
Nickenig, G, Estevez-Loureiro, R, Franzen, O, Tamburino, C, Vanderheyden, M, Luscher, Tf, Moat, N, Price, S, Dall'Ara, G, Winter, R, Corti, R, Grasso, C, Snow, Tm, Jeger, R, Blankenberg, S, Settergren, M, Tiroch, K, Balzer, J, Petronio, A, Buttner, Hj, Ettori, F, Sievert, H, Fiorino, Mg, Claeys, M, Ussia, Gp, Baumgartner, H, Scandura, S, Alamgir, F, Keshavarzi, F, Colombo, A, Maisano, F, Ebelt, H, Aruta, P, Lubos, E, Plicht, B, Schueler, R, Pighi, M, Di Mario, C, Transcatheter Valve Treatment Sentinel Registry Investigators of the, Erpotesoc |
| Popis: |
The use of transcatheter mitral valve repair (TMVR) has gained widespread acceptance in Europe, but data on immediate success, safety, and long-term echocardiographic follow-up in real-world patients are still limited.The aim of this multinational registry is to present a real-world overview of TMVR use in Europe.The Transcatheter Valve Treatment Sentinel Pilot Registry is a prospective, independent, consecutive collection of individual patient data.A total of 628 patients (mean age 74.2 ± 9.7 years, 63.1% men) underwent TMVR between January 2011 and December 2012 in 25 centers in 8 European countries. The prevalent pathogenesis was functional mitral regurgitation (FMR) (n = 452 [72.0%]). The majority of patients (85.5%) were highly symptomatic (New York Heart Association functional class III or higher), with a high logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation) (20.4 ± 16.7%). Acute procedural success was high (95.4%) and similar in FMR and degenerative mitral regurgitation (p = 0.662). One clip was implanted in 61.4% of patients. In-hospital mortality was low (2.9%), without significant differences between groups. The estimated 1-year mortality was 15.3%, which was similar for FMR and degenerative mitral regurgitation. The estimated 1-year rate of rehospitalization because of heart failure was 22.8%, significantly higher in the FMR group (25.8% vs. 12.0%, p[log-rank] = 0.009). Paired echocardiographic data from the 1-year follow-up, available for 368 consecutive patients in 15 centers, showed a persistent reduction in the degree of mitral regurgitation at 1 year (6.0% of patients with severe mitral regurgitation).This independent, contemporary registry shows that TMVR is associated with high immediate success, low complication rates, and sustained 1-year reduction of the severity of mitral regurgitation and improvement of clinical symptoms. |
