Food significantly reduces plasma concentrations of first-line anti-tuberculosis drugs

Autor:	Agibothu Kupparam Hemanth Kumar, Vedachalam Chandrasekaran, Angadi Kiran Kumar, M Kawaskar, J Lavanya, Soumya Swaminathan, Geetha Ramachandran
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Adult Male food lcsh:R Antitubercular Agents lcsh:Medicine India Fasting Middle Aged Pyrazinamide tuberculosis Anti-tuberculosis drug concentrations Isoniazid Humans Original Article Female Rifampin Anti-tuberculosis drug concentrations - food - pharmacokinetics - tuberculosis pharmacokinetics
Zdroj:	The Indian Journal of Medical Research Indian Journal of Medical Research, Vol 145, Iss 4, Pp 530-535 (2017)
ISSN:	0971-5916
Popis:	Background & objectives: Concomitant feeding and anti-tuberculosis (TB) drug administration are likely to reduce nausea and enhance compliance to treatment. However, food could lower plasma drug concentrations. This study was undertaken to examine the effect of food on two-hour plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA), and pharmacokinetics of these drugs in adult TB patients. Methods: Newly diagnosed adult TB patients were recruited from the Revised National Tuberculosis Control Programme (RNTCP) treatment centres in Chennai Corporation, Chennai, India. Two-hour post-dosing plasma concentrations were determined in 25 patients, and a semi-intensive pharmacokinetic study was undertaken in six patients. RMP, INH and PZA concentrations were determined by high-performance liquid chromatography. Results: The geometric mean two-hour concentrations with food and under fasting conditions were 2.2 and 5.5 μg/ml for RMP (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7759bec62146c815c9dd766fd17e6886 http://europepmc.org/articles/PMC5663168 Zobrazit plný text záznamu Plný text ve formátu PDF