Synergistic effects of ad-libitum low-dose fructose drinking and low-dose streptozotocin treatment in wistar rats: A mild model of type 2 diabetes
| Autor: | Asie Sadeghi, Beigy, M., Alizadeh, S., Mazloom, H., Vakili, S., Ahmadi, S., Meshkani, R. |
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| Předmět: |
Blood Glucose
Male lcsh:R5-920 Streptozotocin Experimental animal model Type 2 diabetes Fructose respiratory system Streptozocin respiratory tract diseases Diabetes Mellitus Experimental Diet Rats Disease Models Animal Diabetes Mellitus Type 2 Hyperglycemia Animals Insulin Resistance Rats Wistar lcsh:Medicine (General) circulatory and respiratory physiology |
| Zdroj: | Scopus-Elsevier Acta Medica Iranica, Vol 55, Iss 5 (2017) |
| Popis: | To develop a convenient animal model of T2D by pretreatment with low-dose 10% w/v fructose (FRC) solution followed by the injection of low doses of streptozotocin (STZ) in Wistar rats. For this 8-week experimental study; rats were first fed a standard chow ad-libitum diet and either tap water (n=40) or 10% w/v FRC solution (n=40) for 4 weeks. Next, rats in each category were randomly allocated to 4 subgroups (n=10 each) of low-dose STZ (25,35, and 45 mg/kg). The final mean fasting blood sugar (FBG) of FRC+STZ45 (197±55.87 mg/dl) were significantly higher than that of the STZ45 (P=0.015) and FRC (P=0.019) groups. FRC+STZ45 showed the highest insulin resistance demonstrated by insulin tolerance test [area under the curve (AUC) of insulin tolerance test; P |
| Databáze: | OpenAIRE |
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