Cellular morphological changes detected by laser scanning in vivo confocal microscopy associated with clinical outcome in fungal keratitis
| Autor: | Chidambaram, Jaya D., Prajna, Namperumalsamy V., Palepu, Srikanthi, Lanjewar, Shruti, Shah, Manisha, Elakkiya, Shanmugam, Lalitha, Prajna, Macleod, David, Burton, Matthew J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male lcsh:Medicine India Acanthamoeba Article Cornea Prognostic markers Odds Ratio Humans Prospective Studies lcsh:Science Corneal Ulcer Cell Nucleus Inflammation Keratitis Microscopy Confocal lcsh:R Middle Aged Prognosis Fungal host response Aspergillus Treatment Outcome lcsh:Q Female Eye Infections Fungal |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| ISSN: | 2045-2322 |
| Popis: | HRT3 in vivo confocal microscopy (IVCM) images may indicate clinical outcome, but few studies have analysed this in fungal keratitis (FK). Adults with FK (diameter ≥3 mm) presenting to Aravind Eye Hospital, India from 2012-3 were enrolled prospectively. IVCM was performed at baseline, days 7, 14 and 21 post-enrolment (+/− 3 days where possible). Specific morphologies were identified in IVCM images by a grader masked to microbiology and clinical outcome (defined as good: healed/improving, or poor: enlarged ulcer, perforation or transplant/glue). Associations with final visit outcome assessed using logistic regression. 143 FK participants were enrolled; 87 had good outcome, 56 had poor outcome. Poor outcomes were associated with stellate interconnected cellular processes with no visible nuclei (OR 2.28, 95% CI: 1.03–5.06, p = 0.043) in baseline IVCM images, and fungal filaments (OR 6.48, 95% CI:2.50–16.78, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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