| Autor: |
G, Ricco, U, Mazza, R M, Turi, P G, Pich, C, Camaschella, G, Saglio, L F, Bernini |
| Přispěvatelé: |
Ricco, G, Mazza, U, Turi, Rm, Pich, Pg, Camaschella, Clara, Saglio, G, Bernini, Lf |
| Jazyk: |
angličtina |
| Rok vydání: |
1976 |
| Předmět: |
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| Popis: |
A new type of hemoglobin F, in which isoleucine in position 75 (E 19) of the gamma chain is replaced by a threonine residue, has been found in 29 out of 32 homozygotes for beta thalassemia. The amount of this hemoglobin ranges from traces to 40% of the total Hb F. The same gamma75 Thr chain is also present in the Hb F of 40% of normal newborns and premature infants examined, of one 14-week-old fetus and in one out of 3 patients with aplastic anemia and raised levels of Hb F. Our results strongly suggest that the synthesis of this new chain is under the control of a gamma gene nonallelic with those coding for Agamma and Ggamma chains. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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