Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

Autor:	Naldi, Aurélien, Hernandez, Céline, Abou-Jaoudé, Wassim, Monteiro, Pedro T., Chaouiya, Claudine, Thieffry, Denis
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	discrete dynamics regulatory circuit logical model lcsh:QP1-981 Physiology Physiology (medical) p53-Mdm2 network Protocols lcsh:Physiology regulatory network
Zdroj:	Frontiers in Physiology, Vol 9 (2018) Frontiers in Physiology
DOI:	10.3389/fphys.2018.00646/full
Popis:	The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::75d5f3a35547a43c7f66fe03929d2eee https://www.frontiersin.org/article/10.3389/fphys.2018.00646/full Zobrazit plný text záznamu