Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems
| Autor: | Vlachou, Pinelopi, Le Goff, Géraldine, Alonso, Carolina, Alvarez, Pedro, Gallard, Jean-François, Fokialakis, Nikolas, Ouazzani, Jamal |
|---|---|
| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
Aquatic Organisms
guanidine alkaloids [SDE.IE]Environmental Sciences/Environmental Engineering [SDV]Life Sciences [q-bio] Invertebrates Article Crambe Sponge Crambe crambe Alkaloids Pyrimidines [CHIM.ANAL]Chemical Sciences/Analytical chemistry Mediterranean Sea Animals Spiro Compounds solid-phase extraction [SDE.BE]Environmental Sciences/Biodiversity and Ecology crambescidins and crambescins Somartex ComputingMilieux_MISCELLANEOUS Ecosystem Guanidine Biotechnology |
| Zdroj: | Marine Drugs Marine drugs Marine drugs, MDPI, 2018, 16 (5), pp.152. ⟨10.3390/md16050152⟩ |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md16050152⟩ |
| Popis: | Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circulation of water with XAD-amberlite solid-phase extraction was validated in an aquarium. In this work, we reported the elicitation of guanidine alkaloid production of Crambe crambe in the presence of Anemonia sulcata, both collected from the Mediterranean Sea. Besides the previously reported crambescidin 359 (1), and crambescidin acid (2), three new compounds were isolated; one carboxylated analog of 1 named crambescidin 401 (3), and two analogs of crambescin B, crambescin B 281 (4) and crambescin B 253 (5). Based on these results, a technology named Somartex® for “Self Operating MARine Trapping Extractor” was patented and built to transfer the concept from closed aquarium systems to open marine ecosystems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|