Perinatal risk factors interacting with catechol O-methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD

Autor: Nijmeijer, J.S., Hartman, C.A., Lambregts-Rommelse, N.N.J., Altink, M.E., Buschgens, C.J.M., Fliers, E.A., Franke, B., Minderaa, R.B., Ormel, J., Sergeant, J.A., Verhulst, F.C., Buitelaar, J.K., Hoekstra, P.J.
Přispěvatelé: Child and Adolescent Psychiatry / Psychology, Science in Healthy Ageing & healthcaRE (SHARE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE)
Rok vydání: 2010
Předmět:
EXPRESSION
Male
AUTISTIC SYMPTOMS
Adolescent
Genotype
Attention-deficit
autism spectrum disorder
Catechol O-Methyltransferase
Polymorphism
Single Nucleotide
behavioral disciplines and activities
Article
Sampling Studies
Genomic disorders and inherited multi-system disorders [IGMD 3]
Methionine
INDEL Mutation
DEFICIT-HYPERACTIVITY DISORDER
Pregnancy
Risk Factors
Surveys and Questionnaires
mental disorders
Perception and Action [DCN 1]
Birth Weight
Humans
Genetic Predisposition to Disease
Interpersonal Relations
Child
Maternal Behavior
POLYMORPHISMS
METAANALYSIS
Netherlands
Serotonin Plasma Membrane Transport Proteins
Mental Health [NCEBP 9]
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
Smoking
5-HTT
PERVASIVE DEVELOPMENTAL DISORDERS
Valine
ANTISOCIAL-BEHAVIOR
ASSOCIATION
COMT
BIRTH-WEIGHT
Attention Deficit Disorder with Hyperactivity
Child Development Disorders
Pervasive
Linear Models
hyperactivity disorder
Female
gene environment
Stereotyped Behavior
Functional Neurogenomics [DCN 2]
Zdroj: Journal of Child Psychology and Psychiatry, 51(11), 1242-1250. Wiley-Blackwell Publishing Ltd
Journal of Child Psychology and Psychiatry and Allied Disciplines, 51, 11, pp. 1242-50
Journal of Child Psychology and Psychiatry, 51(11), 1242-1250. Wiley
Journal of Child Psychology and Psychiatry and Allied Disciplines, 51, 1242-50
ISSN: 0021-9630
Popis: Contains fulltext : 89792.pdf (Publisher’s version ) (Closed access) BACKGROUND: Symptoms of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) often co-occur. Given the previously found familiality of ASD symptoms in children with ADHD, addressing these symptoms may be useful for genetic association studies, especially for candidate gene findings that have not been consistently replicated for ADHD. METHODS: We studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the serotonin transporter (SLC6A4/SERT/5-HTT) 5-HTTLPR insertion/deletion polymorphism with ASD symptoms in children with ADHD, and whether these polymorphisms would interact with pre- and perinatal risk factors, i.e., maternal smoking during pregnancy and low birth weight. Analyses were performed using linear regression in 207 Dutch participants with combined type ADHD of the International Multicenter ADHD Genetics (IMAGE) study, and repeated in an independent ADHD sample (n =439) selected from the TRracking Adolescents' Individual Lives Survey (TRAILS). Dependent variables were the total and subscale scores of the Children's Social Behavior Questionnaire (CSBQ). RESULTS: No significant main effects of COMT Val158Met, 5-HTTLPR, maternal smoking during pregnancy and low birth weight on ASD symptoms were found. However, the COMT Val/Val genotype interacted with maternal smoking during pregnancy in increasing stereotyped behavior in the IMAGE sample (p =.008); this interaction reached significance in the TRAILS sample after correction for confounders (p =.02). In the IMAGE sample, the 5-HTTLPR S/S genotype interacted with maternal smoking during pregnancy, increasing problems in social interaction (p =.02), and also interacted with low birth weight, increasing rigid behavior (p =.03). Findings for 5-HTTLPR in the TRAILS sample were similar, albeit for related CSBQ subscales. CONCLUSIONS: These findings suggest gene-environment interaction effects on ASD symptoms in children with ADHD. 01 november 2010
Databáze: OpenAIRE
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