Expression of measles virus antigens in Streptococcus gordonii

Autor:	Maggi, T., Oggioni, M. R., DONATA MEDAGLINI, Bianchi Bandinelli, Maria Letizia, Soldateschi, D., Wiesmüller, K. H., Muller, C. P., Valensin, Pier Egisto, GIANNI POZZI
Přispěvatelé:	Maggi T, Oggioni MR, Medaglini D, Bianchi Bandinelli ML, Soldateschi D, Wiesmüller KH, Muller CP, Valensin PE, Pozzi G
Rok vydání:	2000
Předmět:	Mice Inbred BALB C Vaccines Synthetic Measles Vaccine Hemagglutinins Viral Streptococcus Recombinant Proteins Mice Antibody Specificity Measles virus vaccine measles Animals Female Antigens Viral Viral Fusion Proteins
Zdroj:	ResearcherID Scopus-Elsevier Università degli Studi di Siena-IRIS
ISSN:	1121-7138
Popis:	The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73099eec8d37ecdf987b6f5146f3b4c3 https://pubmed.ncbi.nlm.nih.gov/10872681 Zobrazit plný text záznamu