Early life nutrition influences susceptibility to chronic inflammatory colitis in later life
| Autor: | Ley, Delphine, Desseyn, Jean-Luc, Gouyer, Valérie, Plet, Ségolène, Tims, Sebastian, Renes, Ingrid, Mischke, Mona, Gottrand, Frédéric |
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| Přispěvatelé: | Lille Inflammation Research International Center - U 995 [LIRIC], Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Lille Inflammation Research International Center (LIRIC) - U995, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Danone Research, Groupe DANONE, This work was supported by funding from the following organizations: Fondation pour la Recherche Médicale, Danone Nutricia Research, Nutricia Research Foundation, Société Francophone de Nutrition Clinique et Métabolisme., We thank A Hubbard (Johns Hopkins University, USA) for the gift of the DPPIV antibody, D Taillieu and M Besegher (Experimental Resources Platform, Lille University), MH Gevaert and RM Siminski (Lille University) for slides, T van Eijndthoven (Nutricia Research, Utrecht) for his support in bacterial DNA isolation. This, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
intestinal microbiota Aging Glycosylation lcsh:Medicine Mice Inbred Strains Weaning Article Inflammatory bowel disease Animals Humans inflammatory colitis Infant Nutritional Physiological Phenomena lcsh:Science Growth Disorders Microvilli Disease model lcsh:R Infant [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Colitis Gastrointestinal Microbiome Intestines Disease Models Animal intestinal maturation Animals Newborn Chronic Disease Body Composition Cytokines Female lcsh:Q Disease Susceptibility nutritional programming [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Scientific Reports Scientific Reports, 2019, 9, pp.18111. ⟨10.1038/s41598-019-54308-6⟩ Scientific Reports, Nature Publishing Group, 2019, 9, pp.18111. ⟨10.1038/s41598-019-54308-6⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-54308-6⟩ |
| Popis: | International audience; The first thousand days of life are a critical time of development in humans during which the risk profile for diseases in later life can be modified. Nevertheless, long-term consequences of early environment on susceptibility to intestinal diseases have not yet been assessed. Using a mouse model of postnatal growth restriction (PNGR), we showed that early life nutrition influences intestinal maturation and gut health in later life. PNGR induced an alteration of the intestinal barrier in pups at weaning, resulting in increased intestinal permeability, and affected gut bacterial colonization. Specifically, pups with PNGR harbored a decreased bacterial diversity, higher Enterococcus spp., Staphylococcus spp., and Escherichia-Shigella spp., and lower Odoribacter spp. and several members of the Lachnospiraceae family. The lack of an efficient intestinal barrier in early life and the dysbiosis induced by PNGR were associated with a higher susceptibility to chronic colitis in adulthood. |
| Databáze: | OpenAIRE |
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