The role and interaction of imprinted genes in human fetal growth

Autor: Moore, GE, Ishida, M, Demetriou, C, Al-Olabi, L, Leon, LJ, Thomas, AC, Abu-Amero, S, Frost, JM, Stafford, JL, Yao, C, Duncan, AJ, Baigel, R, Brimioulle, M, Iglesias-Platas, I, Apostolidou, S, Aggarwal, R, Whittaker, JC, Syngelaki, A, Nicolaides, KH, Regan, L, Monk, D, Stanier, P
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Life Sciences & Biomedicine - Other Topics
EXPRESSION
chorionic villus sampling
placenta
type 1 diabetes
Review Article
MICE LACKING
EVOLUTIONARY CONSERVATION
fetal growth restriction
Fetal Development
Genomic Imprinting
BECKWITH-WIEDEMANN SYNDROME
Insulin-Like Growth Factor II
Pregnancy
Birth Weight
Humans
Biology
DNA METHYLATION
PCNA-BINDING DOMAIN
11 Medical and Health Sciences
Evolutionary Biology
Science & Technology
POSTNATAL-GROWTH
HUMAN PLACENTA
HUMAN GRB10
Calcium-Binding Proteins
birth weight
Gene Expression Regulation
Developmental
Membrane Proteins
Nuclear Proteins
DIABETES-MELLITUS
Receptors
Somatomedin
Articles
06 Biological Sciences
ALLELIC EXPRESSION
INSULIN
BIRTH-WEIGHT
genomic imprinting
SILVER-RUSSELL-SYNDROME
MAMMALIAN DEVELOPMENT
Intercellular Signaling Peptides and Proteins
Female
Chorionic Villi
Life Sciences & Biomedicine
Zdroj: Philosophical Transactions of the Royal Society B: Biological Sciences
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Moore, G E, Ishida, M, Demetriou, C, Al-Olabi, L, Leon, L J, Thomas, A C, Abu-Amero, S, Frost, J M, Stafford, J L, Yao Chaoqun, N V, Duncan, A J, Baigel, R, Brimioulle, M, Iglesias-Platas, I, Apostolidou, S, Aggarwal, R, Whittaker, J C, Syngelaki, A, Nicolaides, K H, Regan, L, Monk, D & Stanier, P 2015, ' The role and interaction of imprinted genes in human fetal growth ', Philosophical Transactions of the Royal Society of London Series B: Biological Sciences, vol. 370, no. 1663, 20140074, pp. 1-12 . https://doi.org/10.1098/rstb.2014.0074
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
ISSN: 1471-2970
0962-8436
Popis: Identifying the genetic input for fetal growth will help to understand common, serious complications of pregnancy such as fetal growth restriction. Genomic imprinting is an epigenetic process that silences one parental allele, resulting in monoallelic expression. Imprinted genes are important in mammalian fetal growth and development. Evidence has emerged showing that genes that are paternally expressed promote fetal growth, whereas maternally expressed genes suppress growth. We have assessed whether the expression levels of key imprinted genes correlate with fetal growth parameters during pregnancy, either early in gestation, using chorionic villus samples (CVS), or in term placenta. We have found that the expression of paternally expressing insulin-like growth factor 2 (IGF2), its receptor IGF2R, and the IGF2/IGF1R ratio in CVS tissues significantly correlate with crown-rump length and birthweight, whereas term placenta expression shows no correlation. For the maternally expressing pleckstrin homology-like domain family A, member 2 (PHLDA2), there is no correlation early in pregnancy in CVS but a highly significant negative relationship in term placenta. Analysis of the control of imprinted expression of PHLDA2 gave rise to a maternally and compounded grand-maternally controlled genetic effect with a birthweight increase of 93/155 g, respectively, when one copy of the PHLDA2 promoter variant is inherited. Expression of the growth factor receptor-bound protein 10 (GRB10) in term placenta is significantly negatively correlated with head circumference. Analysis of the paternally expressing delta-like 1 homologue (DLK1) shows that the paternal transmission of type 1 diabetes protective G allele of rs941576 single nucleotide polymorphism (SNP) results in significantly reduced birth weight (2132 g). In conclusion, we have found that the expression of key imprinted genes show a strong correlation with fetal growth and that for both genetic and genomics data analyses, it is important not to overlook parent-of-origin effects.
Databáze: OpenAIRE
Externí odkaz: