[Post-translational regulation of N-glycosylated proteins expression in human intestinal cells in culture]
| Autor: | Ogier-Denis , E., Sapin , Christian, Bauvy , C., Hourri , J. J., Aubery , M., Trugnan , G., Codogno , P. |
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| Přispěvatelé: | Archéologies, Cultures et Sociétés (ACS), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Trafic Membranaire et Signalisation Dans les Cellules Epitheliales, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC), Archéologies, Cultures et Sociétés ( ACS ), Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Perron, Nicolas |
| Jazyk: | francouzština |
| Rok vydání: | 1991 |
| Předmět: |
Cell Transformation
Neoplastic Drug Stability Leupeptins Polysaccharides [ CHIM.ORGA ] Chemical Sciences/Organic chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Colonic Neoplasms Tumor Cells Cultured Humans Adenocarcinoma [CHIM.ORGA] Chemical Sciences/Organic chemistry Protein Processing Post-Translational Glycoproteins |
| Zdroj: | C R Seances Soc Biol Fil C R Seances Soc Biol Fil, 1991, 185 ((4)), pp.182-9 |
| Popis: | International audience; HT-29 cells derived from a human colonic adenocarcinoma, can express a typical intestinal differentiation. Undifferentiated HT-29 cells accumulate N-linked glycoproteins substituted with unprocessed carbohydrate chains before to degrade them. Conversely, carbohydrate chains of N-linked glycoproteins are classically processed in differentiated HT-29 cells. The instability of N-linked glycoproteins in undifferentiated HT-29 cells is due to their rapid delivery from the endoplasmic reticulum to a compartment with lysosomal characteristics. This catabolitic pathway involves a bypass of the Golgi apparatus. |
| Databáze: | OpenAIRE |
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