p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
| Autor: | Gloria Bottini, F, Banci, M, Saccucci, P, Neri, A, Bottini, E, Magrini, A |
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| Rok vydání: | 2012 |
| Předmět: |
Male
p53 Codon Polymorphism Single Nucleotide Tumor Suppressor Protein p53 Humans Infant Newborn Aged Protein Tyrosine Phosphatases Alleles Proto-Oncogene Proteins Hospitalization Genetic Predisposition to Disease Coronary Artery Disease Female Infant Single Nucleotide Newborn Clinical Research Settore MED/44 - Medicina del Lavoro CAD Polymorphism ACP1 |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | Summary Background Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACP1) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACP1 is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD. Material/Methods The study included 381 patients admitted to the hospital for cardiovascular disease (232 patients with CAD and 149 with other cardiovascular problems) and 97 healthy newborns. Results The proportion of subjects carrying the *Pro allele of p53 codon 72 and the high activity *B*C genotype of ACP1 is higher in CAD (10.3%) than in non-CAD patients (2.0%) and in healthy newborns (6.2%). Conclusions The data suggest an interaction between p53 codon 72 and ACP1 wherein a positive effect of the p53 *Pro allele on susceptibility to CAD occurs, but only in the presence of the ACP1 genotype characterized by high enzymatic activity. |
| Databáze: | OpenAIRE |
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