Decellularized Tissue for Muscle Regeneration
| Autor: | Urciuolo, A., De Coppi, P. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Biochemistry & Molecular Biology
Chemistry Multidisciplinary Review ANGIOGENESIS lcsh:Chemistry SATELLITE CELLS skeletal muscle regeneration EXTRACELLULAR-MATRIX Animals Humans Regeneration BIOMATERIALS Acellular muscle Acellular tissue Decellularized muscle Decellularized tissue Skeletal muscle engineering Skeletal muscle regeneration Tissue engineering Volumetric muscle loss Allografts Extracellular Matrix Heterografts Muscles lcsh:QH301-705.5 volumetric muscle loss Science & Technology decellularized muscle SCAFFOLD STEM-CELL NICHE MODEL REPLACEMENT Chemistry DIFFERENTIATION lcsh:Biology (General) lcsh:QD1-999 tissue engineering Physical Sciences SKELETAL-MUSCLE acellular tissue decellularized tissue skeletal muscle engineering Life Sciences & Biomedicine acellular muscle |
| Zdroj: | International Journal of Molecular Sciences, Vol 19, Iss 8, p 2392 (2018) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure and composition of the extracellular matrix (ECM) are preserved. Such scaffolds retain biological activity, are biocompatible and do not show immune rejection upon allogeneic or xenogeneic transplantation. An increase number of reports suggest that decellularized tissues/organs are promising candidates for clinical application in patients affected by VML. Here we explore the different strategies used to generate decellularized matrix and their therapeutic outcome when applied to treat VML conditions, both in patients and in animal models. The wide variety of VML models, source of tissue and methods of decellularization have led to discrepant results. Our review study evaluates the biological and clinical significance of reported studies, with the final aim to clarify the main aspects that should be taken into consideration for the future application of decellularized tissues in the treatment of VML conditions. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:19 issue:8 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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