| Autor: |
Vv, Tertov, Ag, Kacharava, Saiadian KhS, Sg, Serebrennikov, Aa, Liakishev, Sg, Kozlov, Na, Gratsianskiĭ, Em, Rogova, Oi, Bocharova, Alexander Orekhov |
| Předmět: |
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| Zdroj: |
Europe PubMed Central |
| Popis: |
In most patients with coronary heart disease (CHD) and angiographically documented stenosed 1-3 coronary arteries, serum contained cholesterol (C) in the circulating immune complexes (CIC), cholesterol levels in these complexes being directly related to serum atherogenicity, i.e. to their ability to cause a 2-5-fold accumulation of lipids in cultured smooth muscle cells (SMC) of the uninvolved human aortic intima (r = 0.91). Removal of IgG and IgM from the patients' sera led to a 75 and 37% decrease, respectively, in their atherogenic properties displayed in cultured SMC. Much more decrease in the atherogenic potential of the sera was seen in 2.5% polyethylene glycol-induced precipitation of CIC. At the same time, incubation of human aortic intimal SMC with CIC isolated from the atherogenic sera from CHD patients caused a 1.5-3-fold increase in intracellular C levels. It was suggested that CIC cholesterol was a determinant of atherogenicity of the sera from patients with coronary atherosclerosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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