Vitamins D3 and K2 may partially counterbalance the detrimental effects of pentosidine in ex vivo human osteoblasts
| Autor: | Sanguineti, R., FIAMMETTA MONACELLI, Parodi, A., Furfaro, A. L., Borghi, R., Pacini, D., Pronzato, M. A., Odetti, P., Molfetta, L., Traverso, N. |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cells
Messenger Osteocalcin Alkaline Phosphatase Antigens Neoplasm Arginine Bone Remodeling Cells Cultured Cholecalciferol Collagen Type I Gene Expression Regulation Humans Lysine Mitogen-Activated Protein Kinases Osteoblasts Osteogenesis Osteoprotegerin RANK Ligand RNA Messenger Vitamin K 2 Antigens Cultured Collagen Type I alpha 1 Chain Neoplasm RNA |
| Zdroj: | Web of Science Scopus-Elsevier |
| ISSN: | 0393-974X |
| Popis: | Osteoporosis is a metabolic multifaceted disorder, characterized by insufficient bone strength. It has been recently shown that advanced glycation end products (AGEs) play a role in senile osteoporosis, through bone cell impairment and altered biomechanical properties. Pentosidine (PENT), a wellcharacterized AGE, is also considered a biomarker of bone fracture. Adequate responses to various hormones, such as 1,25-dihydroxyvitamin D |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|