Association of COVID-19 Lockdown With the Tumor Burden in Patients With Newly Diagnosed Metastatic Colorectal Cancer
| Autor: | Thierry, Alain, Pastor, Brice, Pisareva, Ekaterina, Ghiringhelli, Francois, Bouché, Olivier, de La Fouchardière, Christelle, Vanbockstael, Julie, Smith, Denis, François, Eric, dos Santos, Mélanie, Botsen, Damien, Ellis, Stephen, Fonck, Marianne, André, Thierry, Guardiola, Emmanuel, Khemissa, Faiza, Linot, Benjamin, Martin-Babau, J., Rinaldi, yves, Assenat, Eric, Clavel, Lea, Dominguez, Sophie, Gavoille, Celine, Sefrioui, David, Pezzella, Veronica, Mollevi, Caroline, ychou, Marc, Mazard, Thibault |
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| Přispěvatelé: | Salvy-Córdoba, Nathalie |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male MESH: Pandemics MESH: Tumor Burden [SDV.CAN]Life Sciences [q-bio]/Cancer Circulating Tumor DNA Cohort Studies MESH: Communicable Disease Control Clinical Trials Phase II as Topic [SDV.CAN] Life Sciences [q-bio]/Cancer Biomarkers Tumor MESH: COVID-19 Humans MESH: SARS-CoV-2 MESH: Cohort Studies Pandemics Aged Randomized Controlled Trials as Topic Original Investigation MESH: Aged MESH: Humans MESH: Middle Aged SARS-CoV-2 MESH: Circulating Tumor DNA Research COVID-19 MESH: Adult MESH: Patient Acceptance of Health Care [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Middle Aged Patient Acceptance of Health Care MESH: Male [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Tumor Burden Online Only MESH: Randomized Controlled Trials as Topic Oncology [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Controlled Before-After Studies Communicable Disease Control [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Female MESH: Biomarkers Tumor Colorectal Neoplasms MESH: Female MESH: Clinical Trials Phase II as Topic MESH: Controlled Before-After Studies MESH: Colorectal Neoplasms |
| Zdroj: | JAMA Network Open JAMA Network Open, American Medical Association, 2021, 4 (9), pp.e2124483. ⟨10.1001/jamanetworkopen.2021.24483⟩ |
| ISSN: | 2574-3805 |
| DOI: | 10.1001/jamanetworkopen.2021.24483⟩ |
| Popis: | This cohort study assesses the association of local and national COVID-19 restrictions with tumor burden, as measured by total plasma circulating tumor DNA concentration, among patients newly diagnosed with metastatic colorectal cancer. Key Points Question What is the implication of the COVID-19 lockdown for the tumor burden of patients with a newly diagnosed metastatic colorectal cancer? Findings In this cohort study of 80 patients with metastatic colorectal cancer, the tumor burden, which was evaluated using the circulating tumor DNA in plasma, appeared to be significantly higher in patients who received a diagnosis after lockdown compared with those who were diagnosed before lockdown (119.2 ng/mL vs 17.3 ng/mL). Patients with greater tumor burden had lower median survival than those with lower tumor burden. Meaning In this study, the tumor burden of colorectal cancer varied and appeared to be associated with poor survival for those who received a postlockdown diagnosis, suggesting that this cancer is a major area for intervention to minimize COVID-19–associated diagnostic delay. Importance The COVID-19 pandemic has been associated with substantial reduction in screening, case identification, and hospital referrals among patients with cancer. However, no study has quantitatively examined the implications of this correlation for cancer patient management. Objective To evaluate the association of the COVID-19 pandemic lockdown with the tumor burden of patients who were diagnosed with metastatic colorectal cancer (mCRC) before vs after lockdown. Design, Setting, and Participants This cohort study analyzed participants in the screening procedure of the PANIRINOX (Phase II Randomized Study Comparing FOLFIRINOX + Panitumumab vs FOLFOX + Panitumumab in Metastatic Colorectal Cancer Patients Stratified by RAS Status from Circulating DNA Analysis) phase 2 randomized clinical trial. These newly diagnosed patients received care at 1 of 18 different clinical centers in France and were recruited before or after the lockdown was enacted in France in the spring of 2020. Patients underwent a blood-sampling screening procedure to identify their RAS and BRAF tumor status. Exposures mCRC. Main Outcomes and Measures Circulating tumor DNA (ctDNA) analysis was used to identify RAS and BRAF status. Tumor burden was evaluated by the total plasma ctDNA concentration. The median ctDNA concentration was compared in patients who underwent screening before (November 11, 2019, to March 9, 2020) vs after (May 14 to September 3, 2020) lockdown and in patients who were included from the start of the PANIRINOX study. Results A total of 80 patients were included, of whom 40 underwent screening before and 40 others underwent screening after the first COVID-19 lockdown in France. These patients included 48 men (60.0%) and 32 women (40.0%) and had a median (range) age of 62 (37-77) years. The median ctDNA concentration was statistically higher in patients who were newly diagnosed after lockdown compared with those who were diagnosed before lockdown (119.2 ng/mL vs 17.3 ng/mL; P |
| Databáze: | OpenAIRE |
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