HLA antigens are risk factors for development of AIDS
| Autor: | Jeannet, Michel, Sztajzel, Roman, Carpentier, N., Hirschel, Bernard, Tiercy, Jean-Marie |
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| Rok vydání: | 1989 |
| Předmět: |
HIV Seropositivity/ immunology
Substance-Related Disorders/complications/immunology Acquired Immunodeficiency Syndrome HLA-D Antigens Substance-Related Disorders Hiv-1 HLA-D Antigens/analysis HLA Antigens/ analysis HLA-C Antigens HLA-DR Antigens Homosexuality HLA-B Antigens/analysis HLA-DR3 Antigen HLA Antigens HLA-B Antigens Risk Factors HIV Seropositivity HIV-1 HLA-DR Antigens/analysis Humans ddc:576.5 HLA-B35 Antigen HLA-C Antigens/analysis Acquired Immunodeficiency Syndrome/complications/ immunology |
| Zdroj: | Journal of Acquired Immune Deficiency Syndromes, Vol. 2, No 1 (1989) pp. 28-32 |
| ISSN: | 0894-9255 1525-4135 |
| Popis: | HLA-A, -B, -C, -DR, and -DQ antigens were determined by serology and in cases of severe lymphopenia by RFLP-DNA typing in 51 Caucasians with a diagnosis of AIDS (32 with opportunistic infections and 19 with secondary cancers). In addition, 86 HIV-1 seropositive and 39 HIV-1 seronegative drug abusers and 148 healthy controls were also studied. No significant differences in HLA antigen frequencies were found in comparison of HIV-1 seropositive and HIV-1 seronegative drug abusers with controls, suggesting that HLA polymorphism does not represent a genetic risk for infection with HIV-1. In contrast, a significant increased frequency of B35 (p less than 0.01) and CW4 (p less than 0.01) was observed in both groups of AIDS patients as compared to controls. Moreover, DR2 was increased in frequency in patients with opportunistic infections (p less than 0.01) and DR3 was completely absent in patients with secondary cancers (p less than 0.05). In the latter group, the DR5 frequency was increased, although nonsignificantly. These findings provide strong evidence for the existence of HLA-linked factors of susceptibility and host resistance to AIDS. |
| Databáze: | OpenAIRE |
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