| Autor: |
Larisch R, Klimke A, Mayoral F, Hamacher K, Hr, Herzog, Vosberg H, Tosch M, Gaebel W, Rivas F, Hh, Coenen, Hw, Müller-Gärtner |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0029-5566 |
| Popis: |
The characteristics of 5HT2 receptor binding were investigated in major depression in vivo using positron emission tomography and the radioligand F-18-altanserin.Twelve patients from families with high loading of depression living in a geographically restricted region were examined and compared with normal control subjects. At the time of the PET measurement all patients were remitted; in some of them remission was sustained by antidepressive medication. Binding potential was assessed by Logan's graphical analysis method.The binding of F-18-altanserin was about 38% lower in patients than in healthy controls (p0.001). A multiple regression analysis revealed that this difference was mainly induced by depression rather than by medication.The data suggest that 5HT2 receptors are altered in depression. We present evidence for a reduction of the receptor density, which might be usable as trait marker of subjects susceptible for depressive illness. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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