Polymyxin B containing polyion complex (PIC) nanoparticles: Improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component

Autor:	Ignacio, Insua, Laimdota, Zizmare, Anna F A, Peacock, Anne Marie, Krachler, Francisco, Fernandez-Trillo
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Ions Drug Carriers Bacteria Molecular Structure Polymers lcsh:R lcsh:Medicine Microbial Sensitivity Tests Article Polymerization Anti-Infective Agents Nanoparticles lcsh:Q lcsh:Science Polymyxin B
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports
ISSN:	2045-2322
Popis:	Here, we describe the preparation and characterisation of polyion complex (PIC) nanoparticles containing last resort antimicrobial polymyxin B (Pol-B). PIC nanoparticles were prepared with poly(styrene sulphonate) (PSS) as an inert component, across a range of degrees of polymerisation to evaluate the effect that multivalency of this electrolyte has on the stability and antimicrobial activity of these nanoparticles. Our results demonstrate that while nanoparticles prepared with longer polyelectrolytes are more stable under simulated physiological conditions, those prepared with shorter polyelectrolytes have a higher antimicrobial activity. Tailoring the degree of polymerisation and the ratio of the components we have been able to identify a formulation that shows a sustained inhibitory effect on the growth of P. aeruginosa and can reduce the number of viable colonies of this pathogen over 10,000 times more effectively than our previously reported formulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6a69afd882f74801527dbb5801eadf19 http://link.springer.com/article/10.1038/s41598-017-09667-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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