Genomic epidemiology reconstructs the introduction and spread of Zika virus in Central America and Mexico
| Autor: | Thézé, J, Li, T, du Plessis, L, Bouquet, J, Kraemer, M, Somasekar, S, Yu, G, de Cesare, M, Balmaseda, A, Kuan, G, Harris, E, Wu, C, Ansari, A, Bowden, R, Faria, N, Yagi, S, Messenger, S, Brooks, T, Stone, M, Bloch, E, Busch, M, Munoz-Medina, J, Gonzalez-Bonilla, C, Wolinsky, S, Lopez, S, Arias, C, Bonsall, D, Chiu, C, Pybus, O |
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| Přispěvatelé: | University of Oxford [Oxford], European Research Council under the European Commission Seventh Framework Program (FP7)/European Research Council grant 614725-PATHPHYLODYN Oxford Martin School Society in Science Branco Weiss Fellowship United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Appeared in article as National Institute of Child Health and Human Development T32HD040128 National Library of Medicine of the NIH R01LM010812 R01LM011965 Wellcome Trust Appeared in article as Wellcome Trust Royal Society of London Appeared in article as Royal Society 204311/Z/16/Z Abbott Laboratories Appeared in article as Abbott Laboratories United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID) Appeared in article as NIH from the National Institute of Allergy and Infectious Diseases R01AI099631 P01AI106695 U19 AI118610 R21AI129455 United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI) Appeared in article as NIH from the National Heart, Lung, and Blood Institute R01 HL105704 Wellcome Trust Appeared in article as Wellcome Trust core award 203141/Z/16/Z |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Immunity Herd Adolescent Sequence Analysis RNA Zika Virus Infection [SDV]Life Sciences [q-bio] transmission Central America Genome Viral Mosquito Vectors Zika Virus phylodynamics bait capture enrichment effective reproductive number metagenomic sequencing Child Preschool genomics Humans “spiked” primer enrichment Metagenomics Child Mexico Brazil Phylogeny |
| Zdroj: | Cell Host and Microbe Cell Host and Microbe, Elsevier, 2018, 23 (6), pp.855-864.e7. ⟨10.1016/j.chom.2018.04.017⟩ |
| ISSN: | 1934-6069 1931-3128 |
| DOI: | 10.1016/j.chom.2018.04.017⟩ |
| Popis: | International audience; The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico. One introduction, likely from Brazil via Honduras, led to most infections and the undetected spread of ZIKV through the region from late 2014. Multiple lines of evidence indicate biannual peaks of ZIKV transmission in the region, likely driven by varying local environmental conditions for mosquito vectors and herd immunity. The spatial and temporal heterogeneity of ZIKV transmission in Central America and Mexico challenges arbovirus surveillance and disease control measures. Thézé et al. examine the genomic epidemiology of Zika virus in Central America and Mexico. Following its likely introduction to Honduras in 2014, the virus spread undetected in the region. Genetic and epidemiological data indicate that biannual transmission peaks occurred, and could potentially be explained by local variation in mosquito abundance. |
| Databáze: | OpenAIRE |
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