A medullary centre for lapping in mice
| Autor: | Dempsey, Bowen, Sungeelee, Selvee, Bokiniec, Phillip, Chettouh, Zoubida, Diem, Séverine, Autran, Sandra, Harrell, Evan R., Poulet, James F. A., Birchmeier, Carmen, Carey, Harry, Genovesio, Auguste, McMullan, Simon, Goridis, Christo, Fortin, Gilles, Brunet, Jean-François |
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| Přispěvatelé: | Fortin, Gilles, Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Macquarie University [Sydney], ANR-17-CE16-0006,HEARTBRAIN,Développement et Physiologie des Neurones Intrinsèques du Cœur(2017), ANR-19-CE16-0029,HOMORESP,Résaux neuronaux homotypiques du contrôle respiratoire(2019), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Macquarie University, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
[SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Science Action Potentials Neural circuits behavioral disciplines and activities Article Mice Tongue Animals Central pattern generators Homeodomain Proteins Mice Knockout Motor Neurons Medulla Oblongata Reticular Formation digestive oral and skin physiology fungi [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology food and beverages Feeding Behavior Jaw Female Function and Dysfunction of the Nervous System Brain Stem Transcription Factors |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) Nature Communications Nature Communications, 2021, 12 (1), pp.6307. ⟨10.1038/s41467-021-26275-y⟩ Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6307. ⟨10.1038/s41467-021-26275-y⟩ |
| ISSN: | 2041-1723 |
| Popis: | It has long been known that orofacial movements for feeding can be triggered, coordinated, and often rhythmically organized at the level of the brainstem, without input from higher centers. We uncover two nuclei that can organize the movements for ingesting fluids in mice. These neuronal groups, IRtPhox2b and Peri5Atoh1, are marked by expression of the pan-autonomic homeobox gene Phox2b and are located, respectively, in the intermediate reticular formation of the medulla and around the motor nucleus of the trigeminal nerve. They are premotor to all jaw-opening and tongue muscles. Stimulation of either, in awake animals, opens the jaw, while IRtPhox2b alone also protracts the tongue. Moreover, stationary stimulation of IRtPhox2b entrains a rhythmic alternation of tongue protraction and retraction, synchronized with jaw opening and closing, that mimics lapping. Finally, fiber photometric recordings show that IRtPhox2b is active during volitional lapping. Our study identifies one of the subcortical nuclei underpinning a stereotyped feeding behavior. Orofacial movements for feeding can be triggered, coordinated and rhythmically organised at the level of the brainstem. Here, the authors show two nuclei can organise the stereotyped movements for ingesting fluids in mammals, these neuronal groups are marked by expression of Phox2b and are located in the intermediate reticular formation of the medulla and around the motor nucleus of the trigeminal nerve. |
| Databáze: | OpenAIRE |
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