[Antibodies against human recombinant erythropoietin: an unusual cause of erythropoietin resistance]
| Autor: | Virón B, Kolta A, Jean-Jacques Kiladjian, Mignon F, Mayeux P, Casadevall N |
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| Jazyk: | francouzština |
| Rok vydání: | 2002 |
| Předmět: |
Erythroid Precursor Cells
Male Drug Resistance Granulocyte-Macrophage Colony-Stimulating Factor Anemia Hematemesis Combined Modality Therapy Recombinant Proteins Angiodysplasia Melena Bone Marrow Isoantibodies Renal Dialysis Immunoglobulin G Tumor Cells Cultured Humans Kidney Failure Chronic Blood Transfusion Leukemia Erythroblastic Acute Digestive System Erythropoietin Cell Division Aged |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0250-4960 |
| Popis: | In a 70 year old man with primary glomerulonephritis, severe anemia occurred after 4 years on hemodialysis and rHu-EPO. The usual mechanisms of EPO-resistance were excluded. A bone marrow sample showed red all aplasia. No circulating EPO could be detected; the serum inhibited the growth of erythroid precursors in bone marrow cultures. Immunoprecipitation identified an IgG anti-EPO, still active against deglycosylated EPO, i.e. directed against the peptidic matrix. Its high neutralising capacity and the absence of any immune abnormality rule out an auto-antibody. Anti-rHu EPO immunisation is a very rare occurrence, made severe by transfusion-dependence and the risk of hemosiderosis. An immuno-modulating treatment can therefore be justified. |
| Databáze: | OpenAIRE |
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