| Autor: |
Paola, Circosta, Chiara, Donini, Susanna, Gallo, Lidia, Giraudo, Loretta, Gammaitoni, Ramona, Rotolo, Federica, Galvagno, Sonia, Capellero, Marco, Basiricò, Monica, Casucci, Massimo, Aglietta, Ivana, Ferrero, Franca, Fagioli, Alessandro, Cignetti, Fabrizio, Carnevale-Schianca, Valeria, Leuci, Dario, Sangiolo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
Cytokine-induced killer lymphocytes (CIK) are a promising alternative to conventional donor lymphocyte infusion (DLI), following allogeneic haematopoietic cell transplantation (HCT), due to their intrinsic anti-tumour activity and reduced risk of graft-versus-host disease (GVHD). We explored the feasibility, anti-leukaemic activity and alloreactive risk of CIK generated from full-donor chimaeric (fc) patients and genetically redirected by a chimeric antigen receptor (CAR) (fcCAR.CIK) against the leukaemic target CD44v6. fcCAR.CIK were successfully ex-vivo expanded from leukaemic patients in complete remission after HCT confirming their intense preclinical anti-leukaemic activity without enhancing the alloreactivity across human leukocyte antigen (HLA) barriers. Our study provides translational bases to support clinical studies with fcCAR.CIK, a sort of biological bridge between the autologous and allogeneic sources, as alternative DLI following HCT. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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