Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction

Autor: Balmforth, Craig, van Bragt, Job J.M.H., Ruijs, Titia, Cameron, James R., Kimmitt, Robert, Moorhouse, Rebecca, Czopek, Alicja, Hu, May Khei, Gallacher, Peter J., Dear, James W., Borooah, Shyamanga, MacIntyre, Iain M., Pearson, Tom M.C., Willox, Laura, Talwar, Dinesh, Tafflet, Muriel, Roubeix, Christophe, Sennlaub, Florian, Chandran, Siddharthan, Dhillon, Baljean, Webb, David J., Dhaun, Neeraj
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Balmforth, C, van Bragt, J J M H, Ruijs, T, Cameron, J, Kimmitt, R A, Moorhouse, R, Czopek, A, Khei, H M, Gallacher, P J, Dear, J, Borooah, S, MacIntyre, I, Pearson, T MC, Willox, L, Talwar, D, Tafflet, M, Roubeix, C, Sennlaub, F, Chandran, S, Dhillon, B, Webb, D J & Dhaun, N 2016, ' Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction ', JCI Insight, vol. 1, no. 20 . https://doi.org/10.1172/jci.insight.89173
JCI Insight
DOI: 10.1172/jci.insight.89173
Popis: BACKGROUND. Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and there is an established association between vasculopathy affecting the kidney and eye. Optical coherence tomography (OCT) is a novel, rapid method for high-definition imaging of the retina and choroid. Its use in patients at high cardiovascular disease risk remains unexplored. METHODS. We used the new SPECTRALIS OCT machine to examine retinal and retinal nerve fiber layer (RNFL) thickness, macular volume, and choroidal thickness in a prospective cross-sectional study in 150 subjects: 50 patients with hypertension (defined as a documented clinic BP greater than or equal to 140/90 mmHg (prior to starting any treatment) with no underlying cause identified); 50 with CKD (estimated glomerular filtration rate (eGFR) 8–125 ml/min/1.73 m2); and 50 matched healthy controls. We excluded those with diabetes. The same, masked ophthalmologist carried out each study. Plasma IL-6, TNF-α , asymmetric dimethylarginine (ADMA), and endothelin-1 (ET-1), as measures of inflammation and endothelial function, were also assessed. RESULTS. Retinal thickness, macular volume, and choroidal thickness were all reduced in CKD compared with hypertensive and healthy subjects (for retinal thickness and macular volume P < 0.0001 for CKD vs. healthy and for CKD vs. hypertensive subjects; for choroidal thickness P < 0.001 for CKD vs. healthy and for CKD vs. hypertensive subjects). RNFL thickness did not differ between groups. Interestingly, a thinner choroid was associated with a lower eGFR (r = 0.35, P
Chorioretinal thinning relates to the degree of inflammation and kidney injury in patients with kidney disease.
Databáze: OpenAIRE
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