Acute renal failure and hypercalcemia as onset in splenic lymphoma
| Autor: | Gasperini, M. L., Gigante, A., Barbano, B., Liberatori, M., ROSARIO CIANCI, Amoroso, A. |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
renal failure splenic lymphoma Biopsy Splenic Neoplasms hypercalcaemia lymphoma vitamin d Acute Kidney Injury Treatment Outcome Calcitriol Chemotherapy Adjuvant Parathyroid Hormone Creatinine hypercalcemia parathyroid hormone-related peptide Hypercalcemia Splenectomy Humans Calcium Female Lymphoma Large B-Cell Diffuse Tomography X-Ray Computed Biomarkers |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1128-3602 |
| Popis: | Hypercalcemia is a rare metabolic disorder in course of B cell lymphoma. The mechanism of hypercalcemia in patients with malignancy may include the increased extrarenal production of vitamin D from tumoral cells or neighboring macrophages, i-PTH or PTHrP from tumoral cells. In this case we reported a 34 years old caucasian woman with acute renal failure and hypercalcemia as onset of splenic lymphoma in absence of abnormal levels of serum vitamin D and PTHrP. Because of dramatic recovery of renal function and hypercalcemia after splenectomy, we can speculate that main mechanism of hypercalcemia is related to vitamin D production from neighboring lymphoma macrophages. |
| Databáze: | OpenAIRE |
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