[Qnr-type quinolone resistance in extended-spectrum beta-lactamase producing enterobacteria in Abidjan, Ivory Coast]

Autor: N, Guessennd, S, Bremont, V, Gbonon, A, Kacou-Ndouba, E, Ekaza, T, Lambert, M, Dosso, P, Courvalin
Přispěvatelé: Laboratoire de bactériologie-virologie, Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Agents antibactériens, Institut Pasteur [Paris], au groupe de chercheurs participant au Programme transversal de recherche (PTR 222) financé par l'Institut Pasteur de Paris., Institut Pasteur [Paris] (IP)
Jazyk: francouzština
Rok vydání: 2008
Předmět:
DNA
Bacterial
MESH: Cote d'Ivoire
MESH: beta-Lactamases
Quinolones
Résistance
Polymerase Chain Reaction
beta-Lactam Resistance
beta-Lactamases
Substrate Specificity
MESH: Body Fluids
MESH: Enterobacteriaceae
Bacterial Proteins
Enterobacteriaceae
Species Specificity
Drug Resistance
Multiple
Bacterial
Humans
MESH: Species Specificity
MESH: Enterobacteriaceae Infections
MESH: Bacterial Proteins
Cross Infection
MESH: Humans
MESH: Quinolones
Enterobacteriaceae Infections
MESH: Cross Infection
qnr
MESH: Polymerase Chain Reaction
MESH: Drug Resistance
Multiple
Bacterial
MESH: DNA
Bacterial
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
MESH: beta-Lactam Resistance
Body Fluids
Bêta-lactamases à spectre élargi
Community-Acquired Infections
Cote d'Ivoire
MESH: Community-Acquired Infections
Genes
Bacterial
MESH: Substrate Specificity
MESH: Genes
Bacterial
Entérobactéries
Zdroj: Pathologie Biologie
Pathologie Biologie, Elsevier Masson, 2008, 56 (7-8), pp.439-46. ⟨10.1016/j.patbio.2008.07.025⟩
Pathologie Biologie, 2008, 56 (7-8), pp.439-46. ⟨10.1016/j.patbio.2008.07.025⟩
ISSN: 0369-8114
DOI: 10.1016/j.patbio.2008.07.025⟩
Popis: International audience; The aim of the study was to show the emergence of the qnr genes in extended spectrum beta-lactamases producing enterobacteria in Abidjan between 2005 and 2006. The whole of 151 strains of extended spectrum beta-lactamases producing enterobacteria were studied: 64 Escherichia coli, 66 Klebsiella pneumoniae, seven Klebsiella oxytoca and 14 Enterobacter spp. isolated from various biological products and from in- and out-patients. The techniques of disks diffusion, double-disk synergy, E-test were respectively used for the antimicrobial susceptibility test, the detection of extended spectrum beta-lactamases and the minimal inhibiting concentration. The bla genes(SHV, TEM, CTXM groups 1, 2, 8, 9), and AmpC were determined by PCR and characterized by sequencing. A global prevalence of 27,2 % (41/151) and rates of 9,9, 14,6, 2,7 % for the qnr genes A, B, A and S were observed. The distribution was 42,9 % for Enterobacter spp, 31,2 % for Escherichia coli, 20,5 % for Klebsiella; 30 strains expressed at least two bla genes; four strains were associated with AmpC. The strains were resistant to the cotrimoxazole (97,6 %), to the céfépime (73,2 %), to the céfoxitine (56,1 %), to the imipénème (0 %) and 43,9 % to all the aminosides. This high qnr gene prevalence associated with several types of bla genes in epidemic matter, the high level of resistance to antibiotics make fear a high risk of the transmission of multi-resistants bacteria and challenge the authorities for a resistance monitoring policy.
Databáze: OpenAIRE
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