Modern imaging methods and preoperative management of pheochromocytoma: review of the literature and case report
| Autor: | Antonio Porcaro, Cavalleri, S., Ballista, C., Righetti, R., Ficarra, V., Malossini, G., Tallarigo, C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Male
Alpha and beta-blockers I 131-metaiodobenzylguanidine Octeotride scintigraphy Pheochromocytoma Preoperative management Preoperative management Adrenal Gland Neoplasms Adrenalectomy Pheochromocytoma I 131-metaiodobenzylguanidine 3-Iodobenzylguanidine Hypertension Biomarkers Tumor Alpha and beta-blockers Humans Radiopharmaceuticals Octeotride scintigraphy Radionuclide Imaging Aged |
| Zdroj: | Scopus-Elsevier |
| Popis: | To discuss the modern imaging techniques and preoperative management of pheochromocytoma and to report on one additional case.A 66-year-old male with an incidentally discovered left adrenal mass is described. The adrenal medulla strongly accumulate 131 I-metaiodobenzylguanidine (MIBG). The patient underwent left adrenalectomy after preoperative therapy with alpha and beta-blockers. The recent literature on pheochromocytoma modern imaging techniques and preoperative management is reviewed.MIBG scintigraphy diagnosed a benign functioning adrenal pheochromocytoma, allowing preoperative medical management. Postoperative workup was unremarkable. Diagnosis of pheochromocytoma was confirmed by immunohistopathology. At 18 months follow-up, the patient is alive and disease-free.Incidentally discovered adrenal masses have to be investigated to detect malignancy and subtle hormonal overproduction. MIBG scintigraphy has a high specificity (100%) in detecting pheochromocytoma, metastasis, surgical residual tumor, local relapse and other adrenal crest tumors. Positive results of octreotide scintigraphy in detecting malignant pheochromocytoma have been reported. Currently, pheochromocytoma removal is a safe operation with mortality rates ranging from 0 to less than 3%. Preoperative alpha adrenergic blockage with phenoxybenzamine or prazosin is important in decreasing the operative risk. Beta-blockers may be necessary for cardiac arrhythmia. Intraoperative invasive monitoring of hemodynamic variables may be both diagnostic and therapeutic of inadequate preoperative management. Lifelong follow-up for patients with pheochromocytoma is important. |
| Databáze: | OpenAIRE |
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