| Autor: |
Mayumi, Senoo, Atsuhito, Tone, Yusuke, Imai, Satoko, Watanabe, Mitsuhiro, Kaneto, Yasuyuki, Shimomura, Sanae, Teshigawara, Tatsuaki, Nakatou |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Acta Medica Okayama. 75(1):103-107 |
| ISSN: |
0386-300X |
| Popis: |
A 43-year-old male with type 2 diabetes, under treatment with 5 mg/day of dapagliflozin, was referred to our hospital with upper left abdominal pain and marked hypertriglyceridemia (triglycerides [TGs], 5,960 mg/dl). He was also on a low-carbohydrate diet that promoted ketosis under sodium glucose cotransporter 2 (SGLT2) inhibitor administration. Polyacrylamide gel electrophoresis revealed a remarkable increase in very-low-den-sity lipoprotein, a TG-rich lipoprotein particle synthesized in the liver using free fatty acids derived from adi-pose tissue. Although SGLT2 inhibitors generally improve the lipid profile, under certain conditions such as a low-carbohydrate diet, they may adversely exacerbate the lipid profile via ketosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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