Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients
| Autor: | Sarah Stryeck, Michaela Gastrager, Vesna Degoricija, Matias Trbušić, Ines Potočnjak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Tobias Madl, Saša Frank |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Time Factors lcsh:Medicine Comorbidity Citric Acid Article Prognostic markers Humans Metabolomics lcsh:Science Aged Aged 80 and over Heart Failure 3-Hydroxybutyric Acid lcsh:R Middle Aged Prognosis ROC Curve Outcomes research Acute Disease Metabolome Tyrosine lcsh:Q Female Citrate 2- and 3- Hydroxybutirate Mortality rate Heart failure Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| Popis: | Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p = 0.005, p = 0.008, p |
| Databáze: | OpenAIRE |
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