The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis
| Autor: | Annus, Tiina, Wilson, Liam R., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Menon, David K., Zaman, Shahid H., Holland, Anthony J., Nestor, Peter J. |
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| Přispěvatelé: | Coles, Jonathan [0000-0003-4013-679X], Menon, David [0000-0002-3228-9692], Zaman, Shahid [0000-0003-1639-6014], Holland, Anthony [0000-0003-4107-130X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Down syndrome Neuroscience(all) 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole Clinical Neurology metabolism [Amyloid beta-Peptides] diagnostic imaging [Amyloidosis] Neuroimaging pathology [Alzheimer Disease] Alzheimer Disease pathology [Gray Matter] mental disorders diagnostic imaging [Cerebral Cortex] Humans ddc:610 Gray Matter gray matter volume pathology [Down Syndrome] Aged Cerebral Cortex Aniline Compounds Amyloid beta-Peptides Brain Diseases Metabolic pathology [Brain Diseases Metabolic] diagnostic imaging [Gray Matter] amyloid Regular Article Amyloidosis Alzheimer's disease cortical thickness Middle Aged diagnostic imaging [Brain Diseases Metabolic] Magnetic Resonance Imaging Thiazoles Ageing Cross-Sectional Studies pathology [Cerebral Cortex] Female pathology [Amyloidosis] Geriatrics and Gerontology diagnostic imaging [Down Syndrome] Developmental Biology |
| Zdroj: | Neurobiology of aging 53, 11-19 (2017). doi:10.1016/j.neurobiolaging.2017.01.009 Neurobiology of Aging |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.01.009 |
| Popis: | People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS underwent structural and amyloid imaging—the latter using Pittsburgh compound B (PIB) to stratify the cohort into PIB-positive (n = 19) and PIB-negative (n = 27). Age-matched controls (n = 30) underwent structural imaging. Group differences in deep gray matter volumetry and cortical thickness were studied. PIB-negative people with DS have neurodevelopmentally atypical brain, characterized by disproportionately thicker frontal and occipitoparietal cortex and thinner motor cortex and temporal pole with larger putamina and smaller hippocampi than controls. In the presence of amyloid neuropathology, the DS brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-DS Alzheimer's disease. Care must be taken to avoid underestimating amyloid-associated morphologic changes in DS due to disproportionate size of some subcortical structures and thickness of the cortex. |
| Databáze: | OpenAIRE |
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