Regional cerebral blood flow study with 99mTc-hexamethyl-propyleneamine oxime single photon emission computed tomography in Alzheimer's and multi-infarct dementia

Autor: Battistin, L., Pizzolato, Gilberto, Dam, M., Ponza, I., Borsato, N., Zanco, P. L., Ferlin, G.
Přispěvatelé: L., Battistin, Pizzolato, Gilberto, M., Dam, I., Ponza, N., Borsato, P. L., Zanco, G., Ferlin
Jazyk: angličtina
Rok vydání: 1990
Předmět:
Male
Cerebral
blood supply
Brain
radionuclide imaging
Dominance
Neuropsychological Tests
Basal Ganglia
diagnostic use
Regional Blood Flow
physiology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Organotechnetium Compound
methods
Technetium Tc 99m Exametazime
diagnostic use
Oxime
Alzheimer Disease
Oximes
Humans
Dominance
Cerebral
Tomography
Aged
Alzheimer Disease
radionuclide imaging
Basal Ganglia
blood supply
Cerebral Cortex
blood supply
Dementia
Multi-Infarct
physiology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Organotechnetium Compounds
diagnostic use
Oximes
physiology
Technetium Tc 99m Exametazime
Tomography
Emission-Computed
Single-Photon
radionuclide imaging
Dominance
Aged
Cerebral Cortex
Tomography
Emission-Computed
Single-Photon
Brain
Organotechnetium Compounds
Middle Aged
blood supply
Dementia
Multi-Infarct
Regional Blood Flow
physiology
Dementia
Female
diagnostic use
Popis: Thirty-four demented patients, 19 with Alzheimer's and 15 with multi-infarct dementia, were studied using single photon emission computed tomography, and 99mTc-hexamethyl-propylenemine oxime as a tracer of regional cerebral perfusion. Tracer activity ratios, determined in cortical and subcortical regions, were compared with those of 11 age-matched controls. In both groups of demented patients, most of the cortical regions showed significant declines in tracer uptake from control values, with the greatest reductions in the parietal cortex. Significantly lower parietal indexes were found in the Alzheimer's patient group as compared both to the control values and to the group of multi-infarct dementia patients. A positive correlation was found between the magnitude of the parietal deficits and the severity of dementia.
Databáze: OpenAIRE
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