[Study of a role of artificial mycobacterial particles in the realization of immunological processes in experimental animal tuberculosis]

Autor: Azaev MSh, Lr, Lebedev, Ga, Kuz Micheva, Tumanov IuV, Nikolai Donchenko, Si, Tat Kov, Ov, Nosareva, Aa, Il Ichev
Předmět:
Zdroj: Europe PubMed Central
Popis: The protective properties of artificial mycobacterial particles versus BCG vaccine were studied in laboratory animals with experimental tuberculosis. The findings of the decreased rate of a tuberculous process and on the increased mean life span in animals inoculated with M. bovis suggest that immunization of guinea-pigs with mycobacterial particles promotes the enhanced development of antituberculous immunity in the animals. The paper proposes a promising method for designing artificial immunogens, the high-polymer antigenic structures that imitates mycobacterial particles.
Databáze: OpenAIRE