Relations of non-motor symptoms and dopamine transporter binding in REM sleep behavior disorder

Autor: Petr Dušek, Veronika Lorenzo y Losada Ibarburu, Ondrej Bezdicek, Irene Dall’antonia, Simona Dostálová, Petra Kovalská, Radim Krupička, Jiří Nepožitek, Tomáš Nikolai, Michal Novotný, Pavla Peřinová, Jan Rusz, Tereza Serranová, Tereza Tykalová, Olga Ulmanová, Zuzana Mecková, Václav Ptáčník, Jiří Trnka, David Zogala, Evžen Růžička, Karel Šonka
Jazyk: angličtina
Předmět:
Zdroj: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
ISSN: 2045-2322
DOI: 10.1038/s41598-019-51710-y
Popis: The aim of this study was to evaluate associations of motor and non-motor symptoms with dopamine transporter binding in prodromal stage of synucleinopathies. We examined 74 patients with idiopathic REM sleep behavior disorder (RBD), which is a prodromal synucleinopathy, and 39 controls using Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Montreal Cognitive Assessment, University of Pennsylvania Smell Identification Test (UPSIT), Farnsworth-Munsell 100 hue test, orthostatic test, Scales for Outcomes in PD-Autonomic, Beck depression inventory-II, State-Trait Anxiety Inventory, and video-polysomnography. Electromyographic muscle activity during REM sleep was quantified according to Sleep Innsbruck-Barcelona criteria. In 65 patients, dopamine transporter single-photon emission computed tomography (DAT-SPECT) imaging was performed, putaminal binding ratio was calculated and scans were classified as normal, borderline, or abnormal. Compared to controls, RBD patients had significantly more severe scores in all examined tests. Patients with abnormal DAT-SPECT had higher MDS-UPDRS motor score (p = 0.006) and higher prevalence of orthostatic hypotension (p = 0.008). Putaminal binding ratio was positively associated with UPSIT score (p = 0.03) and negatively associated with tonic (p = 0.003) and phasic (p = 0.01) muscle activity during REM sleep. These associations likely reflect simultaneous advancement of underlying pathology in substantia nigra and susceptible brainstem and olfactory nuclei in prodromal synucleinopathy.
Databáze: OpenAIRE
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