Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers
| Autor: | Chabab, Ghita, Boissière-Michot, Florence, Mollevi, Caroline, Ramos, Jeanne, Lopez-Crapez, Evelyne, Colombo, Pierre-Emmanuel, Jacot, William, Bonnefoy, Nathalie, LAFONT, Virginie |
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| Přispěvatelé: | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut du Cancer de Montpellier (ICM), LAFONT, Virginie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
[SDV.IMM] Life Sciences [q-bio]/Immunology
Astrophysics::High Energy Astrophysical Phenomena TNM staging [SDV.CAN]Life Sciences [q-bio]/Cancer γδ T-cell Article immune infiltrate Lymphocytes Tumor-Infiltrating lcsh:Biology (General) [SDV.CAN] Life Sciences [q-bio]/Cancer Cell Line Tumor Neoplasms immunohistochemistry Humans tumor microenvironment cancer [SDV.IMM]Life Sciences [q-bio]/Immunology lcsh:QH301-705.5 |
| Zdroj: | Cells Cells, MDPI, 2020, 9 (6), pp.E1537. ⟨10.3390/cells9061537⟩ Cells, Vol 9, Iss 1537, p 1537 (2020) Volume 9 Issue 6 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells9061537⟩ |
| Popis: | &gamma &delta T-cells contribute to the immune response against many tumor types through their direct cytolytic functions and their capacity to recruit and regulate the biological functions of other immune cells. As potent effectors of the anti-tumor immune response, they are considered an attractive therapeutic target for immunotherapies, but their presence and abundance in the tumor microenvironment are not routinely assessed in patients with cancer. Here, we validated an antibody for immunohistochemistry analysis that specifically detects all &gamma T-cell subpopulations in healthy tissues and in the microenvironment of different cancer types. Tissue microarray analysis of breast, colon, ovarian, and pancreatic tumors showed that &gamma T-cell density varies among cancer types. Moreover, the abundance of &gamma tumor-infiltrating lymphocytes was variably associated with the outcome depending on the cancer type, suggesting that &gamma T-cell recruitment is influenced by the context. These findings also suggest that &gamma T-cell detection and analysis might represent a new and interesting diagnostic or prognostic marker. |
| Databáze: | OpenAIRE |
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