Change in cardio-protective medication and health-related quality of life after diagnosis of screen-detected diabetes: Results from the ADDITION-Cambridge cohort

Autor: Black, JA, Long, GH, Sharp, SJ, Kuznetsov, L, Boothby, CE, Griffin, SJ, Simmons, RK
Přispěvatelé: Sharp, Stephen [0000-0003-2375-1440], Boothby, Clare [0000-0001-9396-8333], Griffin, Simon [0000-0002-2157-4797], Simmons, Rebecca [0000-0002-7726-8529], Apollo - University of Cambridge Repository
Rok vydání: 2015
Předmět:
Zdroj: Diabetes Research and Clinical Practice
ISSN: 0168-8227
DOI: 10.1016/j.diabres.2015.04.013
Popis: Highlights • We examined individuals with screen-detected diabetes over five years. • Two cardio-protective agents were prescribed at diagnosis, 3 at one year and 4 at five years. • Increases in cardio-protective medication did not impact negatively on HRQoL.
Aims Establishing a balance between the benefits and harms of treatment is important among individuals with screen-detected diabetes, for whom the burden of treatment might be higher than the burden of the disease. We described the association between cardio-protective medication and health-related quality of life (HRQoL) among individuals with screen-detected diabetes. Methods 867 participants with screen-detected diabetes underwent clinical measurements at diagnosis, one and five years. General HRQoL (EQ5D) was measured at baseline, one- and five-years, and diabetes-specific HRQoL (ADDQoL-AWI) and health status (SF-36) at one and five years. Multivariable linear regression was used to quantify the association between change in HRQoL and change in cardio-protective medication. Results The median (IQR) number of prescribed cardio-protective agents was 2 (1 to 3) at diagnosis, 3 (2 to 4) at one year and 4 (3 to 5) at five years. Change in cardio-protective medication was not associated with change in HRQoL from diagnosis to one year. From one year to five years, change in cardio-protective agents was not associated with change in the SF-36 mental health score. One additional agent was associated with an increase in the SF-36 physical health score (2.1; 95%CI 0.4, 3.8) and an increase in the EQ-5D (0.05; 95%CI 0.02, 0.08). Conversely, one additional agent was associated with a decrease in the ADDQoL-AWI (−0.32; 95%CI −0.51, −0.13), compared to no change. Conclusions We found little evidence that increases in the number of cardio-protective medications impacted negatively on HRQoL among individuals with screen-detected diabetes over five years.
Databáze: OpenAIRE
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