[Effect of melatonin and epithalamin on activity of marker enzymes in the cell membrane in the forebrain of rats under acute hypoxia]

Autor:	Ii, Zamors Kyĭ, Vasilij Pishak, If, Meshchyshen
Rok vydání:	2000
Předmět:	Male Prosencephalon Cell Membrane Animals Sodium-Potassium-Exchanging ATPase Hypoxia Peptides 5'-Nucleotidase Biomarkers Melatonin Rats
Zdroj:	Europe PubMed Central
Popis:	The effects of a single-shot intraperitoneally administration of melatonin in a dose of 1 mg per kg body weight and epithalamin in a dose of 2.5 mg per kg body weight on the activities of Na+, K(+)-ATPase and 5'-nucleotidase were investigated in the forebrain of juvenile male white rats under the acute hypobaric hypoxia. The melatonin and epithalamin administration against the background of acute hypoxia prevented an acute hypoxia inducing decrease in the activity of Na+, K(+)-ATPase as well as increased in the activity of 5'-nucleotidase. Such effects of pineal hormones can promote antihypoxic protection of neurons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::60adca71bfc37bf2505bd599034b0b88 https://pubmed.ncbi.nlm.nih.gov/10820844 Zobrazit plný text záznamu