Antimicrobial resistance in Shigella - rapid increase & widening of spectrum in Andaman Islands, India

Autor:	DEBDUTTA BHATTACHARYA, Sugunan, A. P., Bhattacharjee, Haimanti, Thamizhmani, R., Sayi, D. S., Thanasekaran, K., Manimunda, Sathya Prakash, Ghosh, A. R., Bharadwaj, A. P., Singhania, M., Roy, Subama
Předmět:	paediatric Adolescent Antibiotic India Infant Microbial Sensitivity Tests Anti-Bacterial Agents diarrhoea resistance frequency Child Preschool Drug Resistance Multiple Bacterial Humans Original Article Shigella Child widening spectrum Dysentery Bacillary
Zdroj:	Web of Science The Indian Journal of Medical Research
Popis:	Background & objectives: Shigellosis is known to be a major cause of acute childhood diarrhoea in Andaman & Nicobar Islands, India. Rapid emergence of antibiotic resistance warrants continuous monitoring of sensitivity pattern of bacterial isolates. We report here the salient findings of an ongoing study on shigellosis in Andaman Islands, India, with regards to change in drug resistance pattern during the past one decade. Method: During 2006-2009, stools samples from 412 paediatric diarrhoea patients were collected and processed for isolation and identification of Shigella spp. Susceptibility to 22 antimicrobial drugs was tested and MICs were determined for 3rd generation cephalosporins, quinolones, amoxicillin-clavulanic acid combination and gentamicin. Drug susceptibility pattern of these isolates were compared with that of 33 isolates obtained during 2000-2002. Results: Shigella isolates were recovered from 50 of 412 stool samples processed. Resistance to ampicillin, nalidixic acid, tetracycline and ciprofloxacin was observed in 100, 96, 94 and 82 per cent of the isolates, respectively. The frequency of resistance to these drugs was significantly (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::607cc6702a436fa849d7841b0d84a6fd https://publons.com/publon/10625040/ Zobrazit plný text záznamu