| Autor: |
Rusconi, L., Castiglione, R., Gozzini, L., Ciomei, M., Molinari, I., Basilico, L., Tiziana RUBINO, Vinayek, R., Gardner, J. D. |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
0014-827X |
| Popis: |
Although bombesin (BN) and substance P share only the C-terminal dipeptide amide, some substance P receptor antagonists are also weak bombesin receptor antagonists. In order to increase the selectivity of the antagonism for the BN receptor, a series of hybrid peptides were synthesized by the solid-phase methodology, and screened on 3T3 fibroblasts for binding and mitogenic activity. The analogues inhibiting BN-induced thymidine incorporation were further tested for peripheral (amylase release and urinary bladder contraction) and central activity (grooming behaviour). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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