Potential antitumor agents. 34.(1) Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from diimidazo[1,2-a: 1,2-c] pyrimidine
Autor: | Andreani, A., Granaiola, M., ALBERTO LEONI, Locatelli, A., Morigi, R., Rambaldi, M., Giorgi, G., Garaliene, V. |
---|---|
Přispěvatelé: | ANDREANI A., GRANAIOLA M., LEONI A., LOCATELLI A., MORIGI R., RAMBALDI M., GIORGI G., GARALIENE V. |
Rok vydání: | 2004 |
Předmět: | |
Zdroj: | Scopus-Elsevier Europe PubMed Central |
ISSN: | 0250-7005 |
Popis: | We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...