Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review
| Autor: | André, Nathalie, Gastinger, Steven, Rebillard, Amelie |
|---|---|
| Přispěvatelé: | Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Maison des sciences de l'homme et de la société de Poitiers (MSHS), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Institut Formation Education Physique et Sportive Angers (IFEPSA), Université Catholique de l'Ouest (UCO), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Activité Physique, Corps, Sport et Santé (APCOSS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.) |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, 2021, 11, pp.774347. ⟨10.3389/fonc.2021.774347⟩ |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2021.774347⟩ |
| Popis: | International audience; A large amount of evidence shows that after a cancer diagnosis, patients significantly reduce their level of physical activity. Usually, this reduction is attributed to cancer-related fatigue. However, to our knowledge, no study has clearly demonstrated that fatigue alters effort-based decision-making in cancer. This mini-review aimed to provide evidence that chronic fatigue in cancer patients causes changes in brain connectivity that impact effort-based decision-making. Indeed, three patterns of activation to compensate for dysfunctional networks have been reported: greater variability in the executive network and hyperactivation in the executive network, which account for less efficient and costly processes in the frontal cortex, and reduced deactivation in the default mode network. Nevertheless, these activation patterns are also observed with other factors, such as anticipatory stressors (worry, rumination or sleep loss), that might also cause reluctance to engage in physical activity. Effort-based decision-making involving weighing costs against benefits and physical activity interventions should increase immediate benefits to facilitate engagement in effortful activities. |
| Databáze: | OpenAIRE |
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