[Expected impact of a quadrivalent HPV vaccine in France]
Autor: | Riethmuller, D., Prétet, J.-L., Denis, F., Aubin, François, Pradat, P., Clavel, C., Dachez, R., Gondry, Jean, Carcopino, X., Mougin, Christiane |
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Přispěvatelé: | Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université libre de Bruxelles (ULB), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Libre de Bruxelles [Bruxelles] ( ULB ) |
Jazyk: | francouzština |
Rok vydání: | 2009 |
Předmět: |
Adolescent
MESH : Uterine Cervical Neoplasms Uterine Cervical Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer MESH : Papillomavirus Vaccines MESH : Cervical Intraepithelial Neoplasia MESH: Papillomavirus Infections [ SDV.CAN ] Life Sciences [q-bio]/Cancer MESH: Markov Chains MESH : Adolescent Humans MESH : Female Papillomavirus Vaccines MESH : France MESH: Models Theoretical MESH : Markov Chains MESH : Papillomavirus Infections MESH: Adolescent MESH: Humans MESH : Models Theoretical Papillomavirus Infections MESH : Humans MESH: Papillomavirus Vaccines Models Theoretical Uterine Cervical Dysplasia Markov Chains MESH: Uterine Cervical Neoplasms MESH: France MESH : Condylomata Acuminata Condylomata Acuminata Female France MESH: Cervical Intraepithelial Neoplasia MESH: Condylomata Acuminata MESH: Female |
Zdroj: | Journal de Gynécologie Obstétrique et Biologie de la Reproduction Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2009, 38 (5), pp.389-95. ⟨10.1016/j.jgyn.2009.04.008⟩ Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2009, 38 (5), pp.389-95. 〈10.1016/j.jgyn.2009.04.008〉 |
ISSN: | 0368-2315 |
Popis: | International audience; OBJECTIVE: To assess the expected impact in France of a quadrivalent HPV 6/11/16/18 vaccine on the occurrence of genital HPV-induced lesions in women. METHODS: A Markov model based on a quadrivalent vaccination of 14-year-old girls as recommended in France was performed to assess the number of subjects needed to vaccinate to prevent an HPV-related event during their lifetime and the expected annual number of cases which could be prevented by vaccination. This model was based on prevalence data reported in four large French studies (EDiTH I-IV) reporting an HPV 6/11/16/18 prevalence of 82% (95% CI: 78.5-85.1) in cervical cancer (CC), 64% (95% CI: 59.7-68.1) in CIN2/3, 34% (95% CI: 28.9-38.1) in low-grade squamous intraepithelial lesions (LSIL) and 83% (95% CI 77.6-87.8) in female external acuminata condylomata (EAC) cases. RESULTS: Using a theoretical vaccine efficacy of 100%, 130 young women need to be vaccinated to prevent a case of CC, 17 for a case of CIN2/3 and 13 for a case of EAC. Immunization of 80% of 14-year-old girls could prevent 2495 CC (72%), 17,985 CIN2/3 (54%), 8004 CIN1 (27%), and 22,531 EAC female cases (65%) in France annually. CONCLUSION: A good adhesion to the preferentially recommended HPV quadrivalent vaccination would thus substantially reduce the burden of female genital lesions in France. |
Databáze: | OpenAIRE |
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