[Expected impact of a quadrivalent HPV vaccine in France]

Autor: Riethmuller, D., Prétet, J.-L., Denis, F., Aubin, François, Pradat, P., Clavel, C., Dachez, R., Gondry, Jean, Carcopino, X., Mougin, Christiane
Přispěvatelé: Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université libre de Bruxelles (ULB), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Libre de Bruxelles [Bruxelles] ( ULB )
Jazyk: francouzština
Rok vydání: 2009
Předmět:
Adolescent
MESH : Uterine Cervical Neoplasms
Uterine Cervical Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH : Papillomavirus Vaccines
MESH : Cervical Intraepithelial Neoplasia
MESH: Papillomavirus Infections
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
MESH: Markov Chains
MESH : Adolescent
Humans
MESH : Female
Papillomavirus Vaccines
MESH : France
MESH: Models
Theoretical
MESH : Markov Chains
MESH : Papillomavirus Infections
MESH: Adolescent
MESH: Humans
MESH : Models
Theoretical
Papillomavirus Infections
MESH : Humans
MESH: Papillomavirus Vaccines
Models
Theoretical
Uterine Cervical Dysplasia
Markov Chains
MESH: Uterine Cervical Neoplasms
MESH: France
MESH : Condylomata Acuminata
Condylomata Acuminata
Female
France
MESH: Cervical Intraepithelial Neoplasia
MESH: Condylomata Acuminata
MESH: Female
Zdroj: Journal de Gynécologie Obstétrique et Biologie de la Reproduction
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2009, 38 (5), pp.389-95. ⟨10.1016/j.jgyn.2009.04.008⟩
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2009, 38 (5), pp.389-95. 〈10.1016/j.jgyn.2009.04.008〉
ISSN: 0368-2315
Popis: International audience; OBJECTIVE: To assess the expected impact in France of a quadrivalent HPV 6/11/16/18 vaccine on the occurrence of genital HPV-induced lesions in women. METHODS: A Markov model based on a quadrivalent vaccination of 14-year-old girls as recommended in France was performed to assess the number of subjects needed to vaccinate to prevent an HPV-related event during their lifetime and the expected annual number of cases which could be prevented by vaccination. This model was based on prevalence data reported in four large French studies (EDiTH I-IV) reporting an HPV 6/11/16/18 prevalence of 82% (95% CI: 78.5-85.1) in cervical cancer (CC), 64% (95% CI: 59.7-68.1) in CIN2/3, 34% (95% CI: 28.9-38.1) in low-grade squamous intraepithelial lesions (LSIL) and 83% (95% CI 77.6-87.8) in female external acuminata condylomata (EAC) cases. RESULTS: Using a theoretical vaccine efficacy of 100%, 130 young women need to be vaccinated to prevent a case of CC, 17 for a case of CIN2/3 and 13 for a case of EAC. Immunization of 80% of 14-year-old girls could prevent 2495 CC (72%), 17,985 CIN2/3 (54%), 8004 CIN1 (27%), and 22,531 EAC female cases (65%) in France annually. CONCLUSION: A good adhesion to the preferentially recommended HPV quadrivalent vaccination would thus substantially reduce the burden of female genital lesions in France.
Databáze: OpenAIRE
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