Topiramate: effects on serum lipids and lipoproteins levels in children
Autor: | Franzoni, E., Verrotti, A., Sarajlija, J., Garone, C., Matricardi, S., Salerno, G. G., Monti, Martina, Chiarelli, F. |
---|---|
Přispěvatelé: | Franzoni E, Verrotti A, Sarajlija J, Garone C, Matricardi S, Salerno GG, Monti M, Chiarelli F. |
Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
Adult
Male Children Epilepsy Serum lipids and lipoproteins Topiramate Adolescent Age Factors Anticonvulsants Apolipoproteins Child Child Preschool Cholesterol Dyslipidemias Female Fructose Humans Infant Lipids Lipoprotein(a) Lipoproteins Lipoproteins HDL Lipoproteins LDL Prospective Studies Time Treatment Outcome Neurology Neurology (clinical) HDL CHILDREN LDL LIPID Preschool TOPIRAMATE lipids (amino acids peptides and proteins) TRIGLYCERIDES |
Popis: | The present controlled study aims to evaluate topiramate (TPM) effect on total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein, very low-density lipoprotein, apolipoproteins A1, B and lipoprotein (a). Seventy patients in evolving age suffering from various types of epilepsy, treated with TPM, (age range: 6 months-22 years) were evaluated before and after 12 months of treatment and compared with 110 sex- and age-matched subjects. At baseline, no significant difference was present between controls and children treated with TPM. After a year, the BMI did not show significant change in adults and remained into respective growth curve. No significant difference in lipids and lipoproteins neither between first and second evaluation nor between patients and controls was found. Some intra-group variation has been noticed: whilst controls maintained similar levels, the 70 patients on TPM monotherapy showed a slight decrease in TC, triglycerides and HDL. These fluctuations, however, occurred in the normal range so neither dietary nor pharmacological treatment of hyperlipidaemia after a year of TPM was necessary. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.