Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import

Autor: Dussart, Philippe, Cartet, Gaëlle, Huguet, Pierre, Lévêque, Nicolas, Hajjar, Christian, Morvan, Jacques, Vanderkerckhove, Julie, Ferret, Karine, Lina, Bruno, Chomel, Jean-Jacques, Norder, Helene
Přispěvatelé: Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Centre National de Référence des Entérovirus, Hospices Civils de Lyon (HCL), Service d'Ophtalmologie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier de la Basse Terre, Service de Santé des Armées, The authors are thankful to Dr. Ghazali, Pejabat Kesihatan Daerah, Malaysia, and Dr. Oberste, CDC, USA for providing us with the VP1 sequence of strain MAA02, to Dr. Chinelatto, Service de Sante´ des Arme´es, 3rd REI, Kourou, French Guiana, and to Dr. Chaud and Dr. Rosire from Cellule Inter-Re´gionale d'epide´miologi, Artilles, French Guiana. The nucleotide sequence data reported in this study will appear in GenBank under accession number AY876167–AY876192.
Rok vydání: 2005
Předmět:
Adult
Male
MESH: Sequence Analysis
DNA
MESH: West Indies
Asia
West Indies
Molecular Sequence Data
Coxsackievirus Infections
MESH: Conjunctivitis
Acute Hemorrhagic
MESH: Enterovirus C
Human
Communicable Diseases
Emerging
Disease Outbreaks
MESH: Child
MESH: French Guiana
Humans
MESH: Communicable Diseases
Emerging
MESH: Disease Outbreaks
OCIS 000.1430
MESH: Phylogeny
Child
Phylogeny
MESH: Humans
MESH: Middle Aged
MESH: Molecular Sequence Data
MESH: Coxsackievirus Infections
MESH: Asia
Adult
Asia/epidemiology
Child
Communicable Diseases
Emerging/*epidemiology/virology
Conjunctivitis
Acute Hemorrhagic/*epidemiology/virology
Coxsackievirus Infections/epidemiology/virology
Disease Outbreaks
Enterovirus C
Human/classification/genetics/*isolation & purification
Female
French Guiana/epidemiology
Humans
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Sequence Analysis
DNA
West Indies/epidemiology
MESH: Adult
Sequence Analysis
DNA
Middle Aged
MESH: Male
Enterovirus C
Human
French Guiana
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
Conjunctivitis
Acute Hemorrhagic
MESH: Female
Zdroj: Journal of Medical Virology
Journal of Medical Virology, Wiley-Blackwell, 2005, 75 (4), pp.559-65. ⟨10.1002/jmv.20304⟩
ISSN: 0146-6615
1096-9071
DOI: 10.1002/jmv.20304⟩
Popis: International audience; An outbreak of acute hemorrhagic conjunctivitis occurred in French Guiana between April and July 2003, with approximately 6,000 cases in the two major cities Kourou and Cayenne. Since acute hemorrhagic conjunctivitis is not a notifiable disease in France, there was no registration of the number of cases. Therefore, these were estimated by comparing the consumption of antibiotic eye drops and ophthalmic ointments during 2002 and 2003. The outbreak rapidly spread into the Caribbean Islands, causing an outbreak in Guadeloupe in October. Viral isolates from conjunctival swabs of 16 patients were confirmed to be enterovirus by PCR directed to the 5' UTR of the genome. The isolates could not be neutralized by the Melnick intersecting pools, but were shown to be CV-A24 variant by limited sequencing within the VP1 and 3C regions of 12 strains. Phylogenetic analysis revealed that they were similar to the genotype III strains causing outbreaks in Korea 2002 and Malaysia 2003. The previous outbreak of conjunctivitis caused by CV-A24 in the Caribbean in the 1980s was also introduced from Asia, and disappeared after 3 years. This new introduction from Asia and its rapid spread into the Caribbean, where the infection disappeared after a few months, indicates that the CV-A24 variant has a different epidemiological pattern in this region compared to South East Asia, since it has not established an endemic infection. It had to be reintroduced from Asia, where it has been circulating since the 1970s.
Databáze: OpenAIRE
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